Ionic Mechanism Underlying Recovery of Rhythmic Activity in Adult Isolated Neurons

Ionic mechanism underlying recovery of rhythmic activity in adult isolated neurons.

Neurons exhibit long-term excitability changes necessary for maintaining proper cell and network activity in response to various inputs and perturbations. For instance, the adult crustacean pyloric network can spontaneously recover rhythmic activity after complete shutdown resulting from permanent removal of neuromodulatory inputs. Dissociated lobster stomatogastric ganglion (STG) neurons have ...

Convergence of Neuronal Activity Phenotype Result from Spontaneous or Induced Activity via a Common Ionic Mechanism in Adult Isolated Neurons

Neuronal processes underlying rhythmic brain activity.

The neuroelectric activity of the brain provides a variety of instances of rhythmic events. The periodicity of such events ranges from milliseconds in the case of the firing of individual neurons t o circadian in the case of certain aspects of the "sleep" EEG. This paper will (be devoted t o a discussion of (i) methodological approaches to the detection and description of s6me of the shorter pe...

Antioxidant Property of Jobelyn as the Possible Mechanism Underlying its Anti-amnesic Activity in Rodents

Introduction: Amnesia or loss of memory is the cardinal hallmark of Alzheimer’s disease (AD), a progressive neurodegenerative disorder associated with ageing process. Although, AD had been discovered over a century ago, drugs which could cure or halt the progression of the disease are yet to see the light of the day. However, there has been a growing interest in the use of phytomedicines with m...

Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons.

Acutely dissociated cell bodies of mouse Purkinje neurons spontaneously fired action potentials at approximately 50 Hz (25 degrees C). To directly measure the ionic currents underlying spontaneous activity, we voltage-clamped the cells using prerecorded spontaneous action potentials (spike trains) as voltage commands and used ionic substitution and selective blockers to isolate individual curre...